Downloads

Presentations

 

2012 HSC National Convention PREDICT-HD: Discovering the earliest signs of HD

Professor Paulsen's presentation includes an overview of PREDICT-HD findings, a look at how these findings can be applied to peoples' daily lives, and a glimpse toward the future of the study and HD research in general.

 

2011 HDSA National Convention PREDICT-HD Luncheon Presentation

Presentation given by PREDICT-HD Principal Investigator Jane Paulsen at the national HDSA meeting. This talk gives an overview of where we've been in PREDICT-HD, and where we want to go as the study continues.

 

Depression in Prodromal Huntington Disease

Presentation given by Eric Epping at the national HSG meeting. This talk focuses on improving the identification and clinical management of depression in HD patients. 

 

2010 HDSA National Convention - PREDICT-HD

This presentation was given June 26, 2010 by PREDICT-HD Principal Investigator Jane Paulsen at the 2010 HDSA National Convention in Raleigh, NC.

 

Self-paced timing detects subtle changes in prodromal Huntington disease

Results from a study on the paced-tapping measure that all PREDICT-HD participants are no doubt familiar with were presented. Researchers concluded that timing precision was significantly poorer in gene-positive individuals when compared to gene negative individuals. With further research, this will allow clinical trials to be targeted toward these symptoms of HD so better treatments can be devised.

 

Challenges assessing functional outcomes in early Huntington disease

2009 World Congress on Huntington's Disease, Vancouver, BC

A poster presented at the World Congress on Huntington's Disease describing how individuals who have tested positive for HD but are not yet clinically diagnosed will first exhibit functional loss in their performance at work. Knowing this, researchers can try to find treatments and therapies that will slow functional loss for as long as possible.

 

Longitudinal change in striatal volume in pre-clinical Huntington's disease

Results from a study are shown that indicate longitudinal change in striatal volume in the brain is observable over a two-year period in those who have tested positive for HD and are within 15 years of estimated disease onset.

 

Evaluation of the multi-center diffusion tensor imaging

June 18-23, 2009 Organization for Human Brain Mapping 15th Annual Meeting, San Francisco, CA

This poster displays results from a study designed to evaluate the site variation of diffusion tensor imaging across seven sites. Diffusion tensor imaging shows brain white matter changes that may occur in association with HD. Results indicated that diffusion tensor imaging produced reliable results across sites.

 

Global and regional brain morphology in subjects with Huntington's disease prior to diagnosis: Part 1 and Part 2

June 18-23, 2009 Organization for Human Brain Mapping 15th Annual Meeting, San Francisco, CA

Part 1 displays research findings showing differences in cortical thickness in the brain for individuals who have been diagnosed with HD but are not symptomatic. The closer such individuals get to anticipated diagnosis, the more noticeable changes in the brain structure become.

Part 2 displays research findings examining global and regional brain structures in individuals who have tested positive for HD but are not symptomatic. All brian measures were found to be abnormal as far as 15 years before estimated motor diagnosis of HD.

 

Cognitive predictors of HD diagnosis: A prospective study of phenoconversion

Authors: Paulsen JS, Langbehn DR, Wang C, Duff K, Beglinger LJ, Carlozzi NE, Quellar S, Stout JC, and the PREDICT-HD Investigators of the Huntington Study Group. 

 

Research Updates, May 2007

Jane S. Paulsen, Hungtington’s Disease: An Update on Latest Research. 

 

PREDICT-HD Site Visit Presentation

Jane S. Paulsen, Neurobiological predictors of Huntington’s disease. 

 

PREDICT-HD Iowa Site Visit

Jane S. Paulsen, Neurobiological predictors of Huntington’s disease. 

 

HD Overview

Jane S. Paulsen, Hungtington’s Disease: An Update on Latest Research. 


PREDICT-HD Update

Jane S. Paulsen, PREDICT-HD Update.